National Centre of Competence in Research – AntiResist:
New approaches to combat antibiotic-resistant bacteria
Today, infections with multidrug resistant pathogens can only be treated with the greatest effort – or not at all. At the same time, current research and development is unable to meet the urgent need for new, effective antibiotics.
One reason for this is that antibiotic research to date is limited to investigating bacteria and antibiotic action under artificial laboratory conditions. In patients, however, fundamentally different conditions exist with bacteria likely adopting different growth or survival properties. However, our knowledge about these processes is fragmentary at best.
The National Centre of Competence in Research (NCCR) AntiResist is developing new research approaches to better understand the physiology of important bacterial pathogens in infected human patients and to exploit this information to develop axenic systems and human tissue models that best simulate in vivo conditions. Our research focuses on four important human pathogens that cause major health problems worldwide.
The assembly and engineering of novel assay systems to monitor growth of bacteria and their response to antibiotics will guide the development of new types of antimicrobial compounds and will help identify novel and innovative antimicrobial strategies. Towards this goal the NCCR embarks on strategic project partnerships with industry actively engaged in antimicrobial R&D.