Pseudomonas aeruginosa
Pseudomonas aeruginosa is an important human pathogen frequently found in life-threatening hospital infections, including pneumonia, sepsis, and burn and wound infections. P. aeruginosa infections are associated with significant mortality, putting immunocompromised people and cystic fibrosis (CF) patients at particular risk.
P. aeruginosa has become a major threat to human health and is classified as a high priority pathogen by the World Health Organization (WHO).
NCCR AntiResist is developing in-vitro models that approximate the physiological state of P. aeruginosa in the human lung. These models are used to uncover key mechanisms of P. aeruginosa infection, tissue response, and therapy.
Significant progress has already been made in identifying the mechanisms by which P. aeruginosa infects human lung tissue, shown in this diagram. You can read about this in more detail in a paper published by the Jenal Lab in June 2024.
Nature Microbiology » Preprint »
There is a video below from Benoît-Joseph Laventie, one of the authors of the paper, where you can see the effects of P. aeruginosa as it infects the human lung tissue.
Leadership of P. aeruginosa research
Prof. Urs Jenal
Prof. Urs Jenal
Deputy Director
Principal Investigator
Research Page »
Prof. Christian van Delden
Prof. Christian van Delden
Research Page »
