Translation

NCCR AntiResist is transforming antibiotic research and discovery by developing laboratory based on conditions observed in patient samples. This innovative in-vitro modelling of in-vivo conditions provides new hope in the fight against antibiotic-resistant infections.models that replicate the real interactions between bacteria and human tissue inside the body.

We are using the patient mimicking in-vitro models to discover novel biology and identify targets that have been systematically overlooked under artificial laboratory conditions, as well as to determine critical mechanisms of available antibiotics and of novel inhibitors under conditions physiologically similar to the human body.

Based on this mechanistic work and engineering of the models for enhanced robustness, predictive power, and testing, we aim to develop simple investigative procedures (assays). These assays will be used for screening natural products, synthetic compounds, and non-conventional approaches facilitating the identification of effective treatments and innovative solutions.

To facilitate the development of these novel anti-infective strategies, we are collaborating with several different industry and pharmaceutical partners aiming at compound screening and optimisation, evaluation of non-conventional antimicrobials, identification of novel antibiotic targets, and prediction of pharmacokinetic/pharmacodynamics (PK/PD) in humans.